Pain-killers or pain-relieving drugs do not address the cause but only counters the symptoms of arthritis like pain and inflammation.
The presence of living tissues in the cartilage can be build up by cartilage-building drugs.
Long term relief at the knee joint can be provided by hyaluronic acid injections. Analgesics and irrigation of joints by cortisone preparations can help in cases of acute inflammation in knee arthritis.
Over-the-counter drug options include non-steroidal anti-inflammatory drugs (NSAID). However stronger NSAIDs are sold only based on prescription.